Terry was enjoying a dream return to action after his four-match ban for racial abuse when he headed the European champions into the lead from a corner after 20 minutes at Stamford Bridge this afternoon.
But 15 minutes later, having given the ball away, he made a recovery tackle on Luis Suarez only to see the Liverpool striker land awkwardly on top of his right leg.
That left Terry in agony and he immediately signaled to the bench.
After around five minutes of treatment on his right knee, the defender was carried off.
Di Matteo said: “He has a problem with his knee and will have an MRI scan tomorrow.
“At the moment we can’t say, we’ll have to wait for the scan which will tell us the extent of the injury. He is certainly a player that is influential for us. We will miss him.”