The daughter of Topshop tycoon Philip Green, Chloe, 21, was seen enjoying a stroll with the 31-year-old footballer and as they strolled hand in hand they appeared to be much more than pals.
Cissé, who is currently divorcing his wife of eight years Jude, appeared to have treated Chloe to a shopping spree and she was seen clutching a Joseph bag with her free hand.
The pair were seen huddled together as they made their way down the street and were seen giggling and chatting together.
The shoe designer was dressed in a pair of tight black jeans, a thick padded jacket and a beige scarf.
Father-of-four Cissé, wore a pair of unusual trainer boots, jeans and a fur-lined jacket.
As well as a shopping trip the pair were also seen enjoying an intimate lunch together in Notting Hill West London.
Chloe had a broad smile plastered across her face as she emerged from the restaurant with the footballer in close pursuit.
The couple were seen sharing a joke together as they walked off from the eatery ahead of shopping.
An onlooker told the Sunday Mirror: 'They couldn't stop laughing and joking, it was really sweet.
'They seemed close and were clearly enjoying each others company, they didn't care who saw them.'
In May Chloe, who has designed her own Topshop shoe range, was seen with England player Defoe, who had ended his relationship with singer Alexandra Burke shortly before.
French Cissé signed for Liverpool in 2004 and has gained a 'bad boy' image after incidents with the police.
He was cautioned for assaulting his pregnant wife Jude and a 15-year-old boy.
A source close to the family said: 'Chloe is not dating Djibril, they are just friends who went on a shopping trip together.'
As well as Defoe, Chloe also enjoyed a relationship with her Made In Chelsea co-star Ollie Lock before he announced he was bisexual.