In an interview with "CBS This Morning," the former secretary of state said, "There is no way that I will do this," when asked if she would accept a position as the No. 2 on this year's Republican presidential ticket.
"Charlie, I didn't run for student council president. I don't see myself in any way in elected office. I love policy. I'm not particularly fond of politics," she told host Charlie Rose, adding that she thinks Romney has "terrific judgment."
Pressed on whether she would turn it down if asked, she said, "I'm saying there is no way that I will do this, because it's really not me. I know my strengths, and governor Romney needs to find someone who wants to run with him."
"There are many people who will do it very, very well, and I'll support the ticket," she said.
Rice spoke over the weekend at a Utah retreat of big Republican donors for Romney and her remarks were widely praised by attendees.
Asked where she disagrees with President Obama on foreign policy, she said she understands "how hard it is to be in the White House," but said the United States cannot "lead from behind.""The United States has to have a view, it has to gather people around that view, and frankly, I think we need to do more of that, and the last several years I think we've been lacking on that front," she said.