Mexican police handed over Sandra Avila Beltran, a 52 year old known as the "Queen of the Pacific", at an airport in the central city of Toluca.
Avila is expected to appear before a federal judge in Florida on charges of criminal conspiracy and drug trafficking.
From at least January 1999 to March 2004, she is accused of belonging to "a drug trafficking organisation dedicated to buying and transporting between Colombia and the United States of America," Mexican prosecutors said in a statement.
Avila was arrested in September 28, 2007, south of Mexico City. Her lawyers had previously won three appeals to avoid her extradition.
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